A new clinical trial is recruiting patients in the following locations: United States. The trial officially began on the March 24, and is planned to complete on June 3, Background: Major depressive disorder MDD is a common, chronic mental illness.
It can take weeks to months for antidepressants to work. Researchers want to test a new drug that might act more rapidly. Eligibility: Adults ages with MDD without psychotic features.
Principal inclusion criteria 1. Multiple myeloma 2. Relapsed multiple myeloma, defined as disease progression while on or after at least 1 prior treatment regimen 5. Received 3 or more prior therapeutic regimens for multiple myeloma 7.
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They will complete surveys about their symptoms. Participants will have an inpatient visit at NIH. Participation may last weeks.
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During the first phase of the study, participants will be tapered off their psychiatric medicines. For 2 weeks they will have a drug-free period. During the second phase participants will take TS or placebo.
They will take TS for 3 weeks and placebo for 3 weeks. In between the 3-week time period, they will have weeks where they will be drug free. Participants will also have the following tests during this time: - Interviews - Physical exams - Psychological tests and surveys about their symptoms - Blood draws and urine samples - They may complete tests of mood and thinking - MRI Magnetic resonance prostate cancer urine test results : Participants will lie in a machine that takes pictures of their brain.
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A cone lowered on their Antibiotikumok kezelése a prostatitis férfiak otthonában will record brain activity. Electrodes will be placed on the skin. Are able to understand the study and can provide your own consent.
Are willing to undergo all study procedures and are available for the duration of the study. Are aged 18 to Have major depressive disorder.
Have a current episode of depression lasting at least 4 weeks. Ability to take oral medication.
Have not responded to at least one antidepressant. For females Invertilitás a krónikus prosztatitisben reproductive potential: use of contraception while in the study and for an additional 4 weeks after stopping the study drug.
For males of reproductive potential: use of condoms or other types of birth control with partner while in the study and for an additional 3 months after stopping the study drug.
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Abstain from alcohol and drug use while in the study. Are taking any medications that might make it unsafe for you to receive TS or might interfere with our study results.
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Have been treated with a reversible monoamine oxidase inhibitor such as phenelzine Nardil and tranylcypromine Parnateclozapine, or electroconvulsive therapy ECT less than 4 weeks before Phase II. Have been treated with fluoxetine, aripiprazole, or brexpiprazole less than 5 weeks before Phase II.
Have ever undergone deep brain stimulation. Have taken ketamine or esketamine for the treatment of depression but did not respond. Are unwilling to stop undergoing one-on-one psychotherapy for the duration of the study.
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Are pregnant or plan to become pregnant in the next 12 to 16 weeks while in the study, or are breast-feeding. Have schizophrenia or any other psychotic disorder.
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Had significant drug or alcohol dependence or abuse in the past 3 months except for nicotine or caffeineor are currently using illicit substances. Have been diagnosed with borderline or antisocial personality disorder. Had a head injury that caused a loss of consciousness for more than 5 minutes for the brain imaging.
Have a medical illness that might make your participation unsafe, such as heart including coronary artery disease, atherosclerotic ischemic stroke, and atrial fibrillationliver, respiratory, blood, immune, or kidney disease or a seizure disorder, based on our evaluation. Have abnormal results on blood and urine tests we will do.
Have significant suicidal or homicidal thoughts. Have a positive HIV test. For brain imaging: Have metal in your body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, or if you were a welder or metal worker, since you may small metal fragments in the eye.
Weigh over lbs and cannot fit into the MRI scanner. Taisho Pharmaceutical Co.